Croscarmellose Sodium

Overview

Croscarmellose Sodium (PARCROS) is a crosslinked sodium carboxymethyl cellulose used as a superdisintegrant in a wide range of oral dosage forms. It offers efficient disintegration at low concentrations through its excellent wicking and swelling properties. Available in multiple grades, PARCROS is suitable for direct compression, wet, and dry granulation, and is widely used in both pharmaceutical and nutraceutical tablets, capsules, ODTs, blends, and granules.

Product Specifications

Parameter	Specification
Settling Volume	10-30 ml
Mesh	95% Pass #100
LOD	NMT 10
Disintegration Time	Improved DT
Water Solubility	NMT 10

Parameter	Specification
Settling Volume	12-28 ml
Mesh	90% Pass #120
LOD	NMT 12
Disintegration Time	Standard DT
Water Solubility	NMT 12

Parameter	Specification
Settling Volume	15-35 ml
Mesh	85% Pass #150
LOD	NMT 15
Disintegration Time	Fast DT
Water Solubility	NMT 15

Parameter	Specification
Settling Volume	20-40 ml
Mesh	80% Pass #180
LOD	NMT 20
Disintegration Time	Slow DT
Water Solubility	NMT 20

Parameter	Specification
Settling Volume	25-45 ml
Mesh	75% Pass #200
LOD	NMT 25
Disintegration Time	Very Slow DT
Water Solubility	NMT 25

Features

Exhibits rapid disintegration and enhanced drug release profiles
Demonstrates superior swelling capacity, leading to faster dissolution rates compared to traditional disintegrants
Offers excellent compatibility and stability with a broad range of active pharmaceutical ingredients (APIs)
Highly effective at low concentrations, minimizing excipient load
Ideal for use in direct compression, wet granulation, and various tableting processes

Applications

Pharmaceutical

Widely used as the primary disintegrant in a multitude of solid oral dosage forms, including tablets and capsules

Nutraceutical

Enhances the disintegration and dissolution of dietary supplements formulated as tablets or capsules

Food

Potential applications may include thickening and stabilizing functions (subject to regional regulations)